Table 1: Significant Stem Cell Research Patents
Patents in three sources:
Patent number | Patent title | Publication date | Assignee |
US 51925531,2,4Boyse, et al. | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use | 3/9/1993 | Pharmastem Therapeutics |
US 51999421,2,4Gillis | Method for improving autologous transplantation | 5/6/1993 | Immunex |
US 54533571,2,4Hogan | Pluripotential embryonic stem cells and methods of making same | 9/26/1995 | Vanderbilt University |
US 57503761,2,4Weiss, et al. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny | 5/12/1998 | Neurospheres |
US 58437802,3,4Thomson | Primate embryonic stem cells | 12/1/1998 | WARF |
US 62008062,3,4Thomson | Primate embryonic stem cells | 3/13/2001 | WARF |
Patents in two sources:
Patent number | Patent title | Publication date | Assignee |
US 52269142,4Caplan, et al. | Method for treating connective tissue disorders | 7/13/1993 | Osiris Therapeutics |
US 53994932,4Emerson, et al. | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures | 3/21/1995 | University of Michigan |
US 54379942,4Emerson, et al. | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells | 8/1/1995 | University of Michigan |
US 54647642,4Capecchi, et al. | Positive-negative selection methods and vectors | 11/7/1995 | First Union National Bank |
US 54863591,2Caplan, et al. | Human mesenchymal stem cells | 1/23/1996 | Osiris Therapeutics |
US 55232262,4Wheeler | Transgenic swine compositions and methods | 6/4/1996 | University of Illinois |
US 55916252,4Gerson, et al. | Transduced mesenchymal stem cells | 1/7/1997 | Case Western Reserve University |
US 56122112,4Wilson, et al. | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors | 3/18/1997 | New York University and Sloan-Kettering Institute |
US 56353872,4Fei, et al. | Methods and device for culturing human hematopoietic cells and their precursors | 6/13/1997 | CellPro |
US 57535061,2Johe | Isolation, propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals | 5/19/1998 | CNS Stem Cell Technology |
US 58518322,4Weiss, et al. | In vitro growth and proliferation of multipotent neural stem cells and their progeny | 12/22/1998 | Neurospheres |
US 59688292,4Carpenter | Human CNS neural stem cells | 10/19/1999 | Stem Cells California |
US 60906222,3Gearhart, et al. | Human embryonic pluripotent germ cells | 7/18/2000 | Johns Hopkins University |
US 61472761,2Campbell, et al. | Quiescent cell populations for nuclear transfer in the production of non-human mammals and non-human mammalian embryos | 11/14/2000 | Roslin Institute |
US 62455662,3Gearhart, et al. | Human embryonic germ cell line and methods of use | 6/12/2001 | Johns Hopkins University |
US 62807183,4Kaufman, et al. | Hematopoietic differentiation of human pluripotent embryonic stem cells | 8/28/2001 | WARF |
US 65626192,3Gearhart, et al. | Differentiation of human embryonic germ cells | 5/13/2003 | Johns Hopkins University |
US 65764642,3Gold, et al. | Methods for providing differentiated stem cells | 6/10/2003 | Geron |
US 66420482,3Xu, et al. | Conditioned media for propagating human pluripotent stem cells | 11/4/2003 | Geron |
US 68004802,3Bodnar, et al. | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture | 10/5/2004 | Geron |
US 68281453,4Avital, et al. | Method for the isolation of stem cells by immuno-labeling with HLA/MHC gene product marker | 12/7/2004 | Cedars-Sinai Medical Center |
Patents in one sources:
Patent number | Patent title | Publication date | Assignee |
US 47146804Civin | Human stem cells | 12/22/1987 | Johns Hopkins University |
WO 90034324Evans, et al. | Derivation of pluripotential embryonic cell lines from domestic animals | 4/5/1990 | Animal Biotechnology Cambridge |
US 50046814Boyse, et al. | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood | 4/2/1991 | Pharmastem |
US 50875702Weissman, et al. | Homogeneous mammalian hematopoietic stem cell composition | 2/11/1992 | Novartis or StemCells |
US 51087532Kuberasampath, et al. | Osteogenic devices | 4/28/1992 | Creative BioMolecules |
WO 92113552Emerson, et al. | Method for culturing and transforming human stem cell–containing compositions | 7/9/1992 | University of Michigan |
US 51660652Williams, et al. | In vitro propagation of embryonic stem cells | 11/24/1992 | Amrad |
US 51753844Krimpenfort, et al. | Transgenic mice depleted in mature T cells and methods for making transgenic mice | 12/29/1992 | GenPharm International |
WO 93012752Weiss, et al. | Novel growth factor responsive progenitor cells which can be proliferated in vitro | 1/21/1993 | Novartis or Stem Cell Therapeutics |
US 51979852Caplan, et al. | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells | 3/30/1993 | Osiris Therapeutics |
WO 93082682Fei, et al. | Methods for selectively expanding stem cells | 4/29/1993 | Cellpro |
WO 94091192Weiss, et al. | Remyelination using neural stem cells | 4/28/1994 | Neurospheres |
WO 94102922Weiss, et al. | Biological factors and neural stem cells | 5/11/1994 | Neurospheres |
US 53407404Petitte, et al. | Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process | 8/23/1994 | North Carolina State University |
US 54057722Ponting | Medium for long-term proliferation and development of cells | 4/11/1995 | Amgen |
WO 95105992Cherny, et al. | Embryonic stem cell–like cells | 4/20/1995 | University of Melbourne |
US 54118832Boss, et al. | Proliferated neuron progenitor cell product and process | 5/2/1995 | Somatix Therapy Corporation |
US 54361514McGlave, et al. | Method for culturing human hematopoietic stem cells in vitro | 7/25/1995 | University of Minnesota |
US 54609644McGlave, et al. | Method for culturing hematopoietic cells | 10/24/1995 | McGlave, Verfaillie, Miller |
US 54879924Capecchi, et al. | Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same | 1/30/1996 | First Union National Bank |
US 55893762Anderson, et al. | Mammalian neural crest stem cells | 12/31/1996 | California Institute of Technology |
WO 97076682Campbell, et al. | Unactivated oocytes as cytoplast recipients for nuclear transfer | 3/6/1997 | Roslin Institute |
US 56353864Palsson, et al. | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture | 6/3/1997 | University of Michigan |
US 56396182Gay | Method of isolating a lineage-specific stem cell in vitro | 6/17/1997 | Plurion |
US 56460432Emerson, et al. | Methods for the ex vivo replication of human stem cells and/or expansion of human progenitor cells | 7/8/1997 | University of Michigan |
US 56703512Emerson, et al. | Methods and compositions for the ex vivo replication of human hematopoietic stem cells | 9/23/1997 | University of Michigan |
US 56703722Hogan | Pluripotential embryonic stem cells and methods of making same | 9/23/1997 | Vanderbilt University |
US 56724992Anderson, et al. | Immortalized neural crest stem cells and methods of making | 9/30/1997 | California Institute of Technology |
US 56909262Hogan | Pluripotential embryonic cells and methods of making same | 11/25/1997 | Vanderbilt University |
US 57285814Schwartz, et al. | Method of expanding hematopoietic stem cells, reagents and bioreceptors for use therein | 3/17/1998 | Novartis |
US 65282451 | Bone marrow cells as a source of neurons for brain and spinal cord repair | 5/7/1999 | University of South Florida |
US 59142682Keller, et al. | Embryonic cell populations and methods to isolate such populations | 6/22/1999 | National Jewish Center for Immunology & Respiratory Medicine |
US 59455771Stice, et al. | Cloning using donor nuclei from proliferating somatic cells | 8/31/1999 | University of Massachusetts |
US 59453374Brown | Method for culturing CD34+ cells in a serum-free medium | 8/31/1999 | Quality Biological |
US 60111971Strelchenko, et al. | Method of cloning bovines using reprogrammed non-embryonic bovine cells | 1/4/2000 | Infigen |
US 61468881Smith, et al. | Method of enriching for mammalian stem cells | 11/14/2000 | University of Edinburgh |
US 61716104Vacanti, et al. | Guided development and support of hydrogel-cell compositions | 1/9/2001 | The Children’s Medical Center Corporation |
WO 010110111Furcht, et al. | Multipotent adult stem cells and methods for isolation | 2/15/2001 | MCL LLC, Furcht, Verfaille, Reyes |
WO 01217671Young, et al. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof | 3/29/2001 | Morphogen Pharmaceuticals |
WO 01397841Abraham, et al. | Pancreatic stem cells and their use in transplantation | 6/7/2001 | The General Hospital Corporation |
US 62878633Hodgson | Method of transferring a DNA sequence to a cell in vitro | 9/11/2001 | Nature Technology Corporation |
US 63262011Fung, et al. | Pancreatic progenitor cells, methods and uses related thereto | 12/4/2001 | Curis |
US 63314063Gearhart, et al. | Human embryonic germ cell and methods of use | 12/18/2001 | Johns Hopkins University |
US 64367011Evans, et al. | Derivation of pluripotential embryonic cell lines from ungulate species | 8/20/2002 | Babraham Institute |
US 64585892Rambhatla, et al. | Hepatocyte lineage cells derived from pluripotent stem cells | 10/1/2002 | Geron Corporation |
US 64792853Vise, et al. | P53 as a regulator of cell differentiation | 11/12/2002 | University of Texas |
US 65282453Sanchez-Ramos, et al. | Bone marrow cells as a source of neurons for brain and spinal cord repair | 3/4/2003 | University of South Florida |
US 65340523Xiao, et al. | Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated | 3/18/2003 | Polystem |
US 65482994Pykett, et al. | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices | 4/15/2003 | Cytomatrix |
US 66027113Thomson, et al. | Method of making embryoid bodies from primate embryonic stem cells | 8/5/2003 | WARF |
US 66077203Xiao, et al. | Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction | 8/19/2003 | Polystem |
US 66387632Steindler, et al. | Isolated mammalian neural stem cells | 10/28/2003 | University of Tennessee |
US 66671763Funk, et al. | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells | 12/23/2003 | Geron |
US 66801982Snyder, et al. | Engraftable human neural stem cells | 1/20/2004 | The Children’s Medical Center Corporation |
US 67592443Alikani, et al. | Composite blastocysts (CBs) from aggregates of dissociated cells of non-viable pre-embryos | 7/6/2004 | Art Institute of New York and New Jersey |
US 67677373Wilson, et al. | Stem cells bearing an FGF receptor on the cell surface | 7/27/2004 | New York University |
US 68756073Reubinoff, et al. | Embryonic stem cells | 4/5/2005 | ES Cell International |
US 68877063Zhang, et al. | Method of in vitro differentiation of transplantable neural precursor cells from primate embryonic stem cells | 5/3/2005 | WARF |
US 69216323Lim, et al. | Human embryonic stem cells derived from frozen-thawed embryo | 7/26/2005 | Maria Biotech |
US 69216653McWhir, et al. | Selective antibody targeting of undifferentiated stem cells | 7/26/2005 | Roslin Institute and Geron |
US 70150373Furcht, et al. | Multipotent adult stem cells and methods for isolation | 2/21/2006 | University of Minnesota |
US 70052523Thomson | Serum free cultivation of primate embryonic stem cells | 2/28/2006 | WARF |
US 70225183Feye | Apparatus and method for co-culturing of cells | 4/4/2006 | Feye, Glen |
US 70299133Thomson | Primate embryonic stem cells | 4/18/2006 | WARF |
US 70302923Yan, et al. | Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same | 4/18/2006 | Stemron |
US 70377202Rao, et al. | Neuroepithelial stem cells and glial-restricted intermediate precursors | 5/2/2006 | University of Utah Research Foundation |
US 70414383Carpenter, et al. | Use of human embryonic stem cells for drug screening and toxicity testing | 5/9/2006 | Geron |
US 70453533Benvenisty | Directed differentiation of human embryonic cells | 5/16/2006 | Yissum Research Development Company |
US 70673164Pykett, et al. | Methods and devices for the long-term culture of hematopoietic progenitor cells | 6/27/2006 | Cytomatrix |
US 70839773Nakatsuji | Monkey-origin embryonic stem cells | 8/1/2006 | Tanabe Seiyaku |
US 71124373Pera | Methods of culturing embryonic stem cells and controlled differentiation | 9/26/2006 | ES Cell International |
US 71124403Abuljadayel | Method of increasing the relative number of CD45 low cells in a cell population | 9/26/2006 | Dhoot, Ghazi |
US 71480623Xu, et al. | Method for generating primate trophoblasts | 12/12/2006 | WiCell Research Institute |
US 71536843Hogan | Pluripotential embryonic stem cells and methods of making same | 12/26/2006 | Vanderbilt University |
US 71760233Kaufman, et al. | Endothelial cells derived from primate embryonic stem cells | 2/13/2007 | WARF |
US 71868833Williams, et al. | In vitro propagation of embryonic stem cells | 3/6/2007 | Zenyth Operations |
US 72020803Ramiya, et al. | Method for transdifferentiation of non-pancreatic stem cells to the pancreatic differentiation pathway | 4/10/2007 | Ixion Biotechnology |
US 72175693Thomson | Clonal cultures of primate embryonic stem cells | 5/15/2007 | Thomson, James |
US 72204123Abuljadayel | Method of preparing an undifferentiated cell | 5/22/2007 | Dhoot, Ghazi |
US 72049794Bjornson, et al. | Generation of hematopoietic cells from multipotent neural stem cells | 4/17/2007 | NeuroSpheres |
US 72558794Hariri | Post-partum mammalian placenta, its use and placental stem cells therefrom | 8/14/2007 | Anthrogenesis |
US 72975394Mandalam, et al. | Medium for growing human embryonic stem cells | 11/20/2007 | Geron |
US 73119054Hariri | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells | 12/25/2007 | Anthrogenesis |
US 73120784Peled, et al. | Methods of controlling proliferation and differentiation of stem and progenitor cells | 12/25/2007 | Gamida Cell |
- UK Stem Cell Initiative Report and Recommendations, 2005.
- Bergman and Graf, Nat. Biotech., 2007.
- Loring, Nat. Reports, 2007.
- Konski and Spielthenner, Nat. Biotech., 2009.